Pacemaker Currents in Dopaminergic Neurones of the Mice Olfactory Bulb
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Dopaminergic Neurones in the Main Olfactory Bulb: An Overview from an Electrophysiological Perspective
The olfactory bulb (OB), the first center processing olfactory information, is characterized by a vigorous life-long activity-dependent plasticity responsible for a variety of odor-evoked behavioral responses. It hosts the more numerous group of dopaminergic (DA) neurones in the central nervous system, cells strategically positioned at the entry of the bulbar circuitry, directly in contact with...
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Puopolo, Michelino, Bruce P. Bean, and Elio Raviola. Spontaneous activity of isolated dopaminergic periglomerular cells of the main olfactory bulb. J Neurophysiol 94: 3618 –3627, 2005. First published July 20, 2005; doi:10.1152/jn.00225.2005. We examined the electrophysiological properties of a population of identified dopaminergic periglomerular cells of the main olfactory bulb using transgeni...
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The neonatal opossum (Monodelphis domestica) was used to assess how different populations of cells are generated in the olfactory region, and how they migrate along pathways to the central nervous system. Developing nerve cells were immunocytochemically labelled using antisera directed against two specific markers of olfactory receptor neurones: olfactory marker protein (OMP) and the dipeptide ...
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Parkinson disease is a multi-system neurodegenerative disease characterized by both motor and non-motor symptoms. Hyposmia is one of the early non-motor symptoms occurring in more than 90% of Parkinson disease cases, which can precede motor symptoms even several years. Up to now, the relationship between hyposmia and Parkinson disease remains elusive. Lack of proper animal models of hyposmia re...
متن کاملSpontaneous activity of isolated dopaminergic periglomerular cells of the main olfactory bulb.
We examined the electrophysiological properties of a population of identified dopaminergic periglomerular cells of the main olfactory bulb using transgenic mice in which catecholaminergic neurons expressed human placental alkaline phosphatase (PLAP) on the outer surface of the plasma membrane. After acute dissociation, living dopaminergic periglomerular cells were identified by a fluorescently ...
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تاریخ انتشار 2017